Autosomal dominant inheritance pattern for trigger thumb.

Notta, in 1850, provided the first clinical description of trigger thumb.1,2 He reported the presence of a nodule on a flexor tendon that was interfering with its gliding motion. Since this first description, the etiology of trigger fingers has been debated. Although a genetic basis has been suspected, the evidence for such in reported cases in the English literature is sparse. We present a pedigree analysis with multiple cases of trigger thumb that supports a genetic basis for this condition.